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1

Novel amino linkers enabling efficient labeling and convenient purification of amino-modified oligonucleotides

Yasuo Komatsu, Naoshi Kojima, Maiko Sugino, Akiko Mikami, Ken Nonaka, Yumi Fujinawa, Takashi Sugimoto, Kousuke Sato, Kenichi Matsubara, Eiko Ohtsuka

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 232 KB

english, 2008

2

Efficient synthesis of oligonucleotide conjugates on solid-support using an (aminoethoxycarbonyl)aminohexyl group for 5′-terminal modification

Naoshi Kojima, Toshie Takebayashi, Akiko Mikami, Eiko Ohtsuka, Yasuo Komatsu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 456 KB

english, 2009

3

Antibodies specific for (6-4) DNA photoproducts: cloning, antibody modeling and construction of a single-chain Fv derivative

Hiroshi Morioka, Hiroyuki Miura, Hiroyuki Kobayashi, Tatsuhiko Koizumi, Kaori Fujii, Kyoichi Asano, Tsukasa Matsunaga, Osamu Nikaido, Jon D Stewart, Eiko Ohtsuka

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1998

Language:

english

File:

PDF, 1.06 MB

english, 1998

4

Utility of Magnetic Resonance Enterography For Small Bowel Endoscopic Healing in Patients With Crohn’s Disease

Takenaka, Kento, Ohtsuka, Kazuo, Kitazume, Yoshio, Matsuoka, Katsuyoshi, Nagahori, Masakazu, Fujii, Toshimitsu, Saito, Eiko, Kimura, Maiko, Fujioka, Tomoyuki, Watanabe, Mamoru

Journal:

American Journal of Gastroenterology

Year:

2017

Language:

english

File:

PDF, 749 KB

english, 2017

5

Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells

Kime, Cody, Kiyonari, Hiroshi, Ohtsuka, Satoshi, Kohbayashi, Eiko, Asahi, Michio, Yamanaka, Shinya, Takahashi, Masayo, Tomoda, Kiichiro

Journal:

Stem Cell Reports

Year:

2019

Language:

english

File:

PDF, 5.44 MB

english, 2019

6

ChemInform Abstract: Construction of Hairpin Ribozymes Containing 4-Thio- and 2-Thiouridine to Investigate the Loop Structures

Izumi Kumagai, Yasuo Komatsu, Eiko Ohtsuka

Journal:

Year:

1999

File:

PDF, 25 KB

1999

7

ChemInform Abstract: Nucleic Acid Syntheses and Molecular Recognition

Journal:

Year:

2000

File:

PDF, 23 KB

2000

8

ChemInform Abstract: Chemical RNA Synthesis (Including RNA with Unusual Constituents)

Yasuo Komatsu, Eiko Ohtsuka

Journal:

Year:

2001

File:

PDF, 24 KB

2001

9

ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis

Takashi Ohtsuka, Takayuki Shiomi, Masayuki Shimoda, Takahide Kodama, Augustin Amour, Gillian Murphy, Eiko Ohuchi, Koichi Kobayashi, Yasunori Okada

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 787 KB

english, 2006

10

27 amino acid residues can be deleted from the N-terminus of human lymphotoxin without impairment of its cytotoxic activity

Satoshi Nishikawa, Noriyuki Matsuo, Yoshitaka Isaka, Seiichi Uesugi, Kazunobu Miura, Eiko Ohtsuka, Ken Takeda, Kunio Konno, Morio Ikehara

Journal:

Journal of Molecular Recognition

Year:

1990

Language:

english

File:

PDF, 604 KB

english, 1990

11

Chemical synthesis of the 5-́half molecule of E.coli tRNA2GLY

Eiko Ohtsuka, Akio Yamane, Takefumi Doi, Morio Ikehara

Journal:

Year:

1984

Language:

english

File:

PDF, 685 KB

english, 1984

12

Large scale synthesis of oligoribonucleotides on a solid support: synthesis of a catalytic RNA duplex

Shigenori Iwai, Toshiro Sasaki, Eiko Ohtsuka

Journal:

Year:

1990

Language:

english

File:

PDF, 947 KB

english, 1990

13

Stereoselective synthesis of dinucleoside phosphate aryl esters by using new condensing reagents, arenesulfonyl 5-(pyridin-2-yl)-tetrazole

Eiko Ohtsuka, Masahiko Shiraishi, Morio Ikehara

Journal:

Year:

1985

Language:

english

File:

PDF, 474 KB

english, 1985

14

Efficient chemical synthesis of a pyrimidine (6–4) pyrimidone photoproduct analog and its properties

Kousuke Satou, Yasuo Komatsu, Takuya Torizawa, Koichi Kato, Ichio Shimada, Osamu Nikaido, Eiko Ohtsuka

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 181 KB

english, 2000

15

Synthesis of oligoribonucleotides by the phosphoramidite approach using 5′-levulinyl and 2′-tetrahydrofuranyl protection

Shigenori Iwai, Eiko Ohtsuka

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 288 KB

english, 1988

16

Formation of phosphodiester linkages by oxidation of a phosphoramidate

Eiko Ohtsuka, Shigeo Morioka, Morio Ikehara

Journal:

Tetrahedron Letters

Year:

1972

Language:

english

File:

PDF, 151 KB

english, 1972

17

Synthesis of a protein biosynthesis inhibitor, 5′-tri-phosphoryladenylyl-(2′-5′)-adenosine

Morio Ikehara, Kazuyuki Oshie, Eiko Ohtsuka

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 176 KB

english, 1979

18

Nucleosides and nucleotides. 126. Incorporation of a mutagenic nucleoside, 5-formyl-2′-deoxyuridine, into an oligodeoxyribonucleotide

Akira Matsuda, Michiyo Inada, Hiroshi Nara, Eiko Ohtsuka, Akira Ono

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 308 KB

english, 1993

19

Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase δ and replication factor C

Takashi Oku, Soichiro Ikeda, Hisashi Sasaki, Kotaro Fukuda, Hiroshi Morioka, Eiko Ohtsuka, Hiroshi Yoshikawa, Toshiki Tsurimoto

Journal:

Year:

1998

Language:

english

File:

PDF, 1.31 MB

english, 1998

20

Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential

Mizue Terai, Yutaka Tamura, Vitali Alexeev, Eiko Ohtsuka, David Berd, Michael J. Mastrangelo, Takami Sato

Journal:

Cancer Immunology, Immunotherapy

Year:

2009

Language:

english

File:

PDF, 374 KB

english, 2009

21

Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue

Naoshi Kojima, Maiko Sugino, Akiko Mikami, Ken Nonaka, Yumi Fujinawa, Isamu Muto, Kenichi Matsubara, Eiko Ohtsuka, Yasuo Komatsu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 262 KB

english, 2006

22

Solid-phase synthesis of protected oligonucleotide blocks : Applications to block condensation on a polymer support and synthesis of a 3'-modified oligonucleotides

Shigenori Iwai, Makoto Koizumi, Morio Ikehara, Eiko Ohtsuka

Journal:

Year:

1987

Language:

english

File:

PDF, 627 KB

english, 1987

23

Effects of 5-methyl substitution in 2′-O-methyloligo-(pyrimidine)nucleotides on triple-helix formation

Miho Shimizu, Tatsuhiko Koizumi, Hideo Inoue, Eiko Ohtsuka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 341 KB

english, 1994

24

Construction of hairpin ribozymes with a three-way junction

Yasuo Komatsu, Miho Shirai, Shigeko Yamashita, Eiko Ohtsuka

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 630 KB

english, 1997

25

Transformation of NIH3T3 Cells with Synthetic c-Ha-ras Genes

Hiroyuki Kamiya, Kazunobu Miura, Noriko Ohtomo, Toshiaki Koda, Mitsuaki Kakinuma, Susumu Nishimura, Eiko Ohtsuka

Journal:

Year:

1989

File:

PDF, 225 KB

1989

26

Transforming Activity of a Synthetic c-Ha-ras Gene Containing O6-Methylguanine in Codon 12

Hiroyuki Kamiya, Kazunobu Miura, Noriko Ohtomo, Susumu Nishimura, Eiko Ohtsuka

Journal:

Year:

1991

File:

PDF, 353 KB

1991

27

Ubiquitous Presence in Mammalian Cells of Enzymatic Activity Specifically Cleaving 8-Hydroxyguanine-containing DNA

Fuyumi Yamamoto, Hiroshi Kasai, Tadayoshi Bessho, Myung-Hee Chung, Hideo Inoue, Eiko Ohtsuka, Tomokatsu Hori, Susumu Nishimura

Journal:

Year:

1992

File:

PDF, 552 KB

1992

28

Comparison of Incorporation and Extension of Nucleotides in vitro opposite 8-Hydroxyguanine (7,8-Dihydro-8-oxoguanine) in Hot Spots of the c-Ha-ras Gene

Hiroyuki Kamiya, Naoko Murata-Kamiya, Masahiro Fujimuro, Kaori Kido, Hideo Inoue, Susumu Nishimura, Chikahide Masutani, Fumio Hanaoka, Eiko Ohtsuka

Journal:

Year:

1995

File:

PDF, 455 KB

1995

29

Effects of a High-Affinity Antibody Fragment on DNA Polymerase Reactions Near a (6–4) Photoproduct Site

Hiroyuki Kobayashi, Kousuke Sato, Yasuo Komatsu, Hiroshi Morioka, Jon D. Stewart, Toshiki Tsurimoto, Eiko Ohtsuka

Journal:

Photochemistry and Photobiology

Year:

1999

Language:

english

File:

PDF, 843 KB

english, 1999

30

Structural differences between a ras oncogene protein and the normal protein

Tong, Liang, de Vos, Abraham M., Milburn, Michael V., Jancarik, Jarmila, Noguchi, Shigeru, Nishimura, Susumu, Miura, Kazunobu, Ohtsuka, Eiko, kim, Sung-Hou

Journal:

Year:

1989

File:

PDF, 427 KB

1989

31

Structural basis for recruitment of human flap endonuclease 1 to PCNA

Sakurai, Shigeru, Kitano, Ken, Yamaguchi, Hiroto, Hamada, Keisuke, Okada, Kengo, Fukuda, Kotaro, Uchida, Makiyo, Ohtsuka, Eiko, Morioka, Hiroshi, Hakoshima, Toshio

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 667 KB

english, 2004

32

Identification of Specific Amino Acid Residues of Adenovirus 12 E1A Involved in Transformation and p300 Binding

Yukiharu Sawada, Masaho Ishino, Kazunobu Miura, Eiko Ohtsuka, Kei Fujinaga

Journal:

Year:

1997

Language:

english

File:

PDF, 312 KB

english, 1997

33

The First Joint Meeting of Biochemistry and Molecular Biology (Sapporo, Japan)

Journal:

Year:

2006

Language:

english

File:

PDF, 58 KB

english, 2006

34

Detailed study of sequence-specific DNA cleavage of triplex-forming oligonucleotides linked to 1,10-phenanthroline

Shimizu, Miho, Inoue, Hideo, Ohtsuka, Eiko

Journal:

Year:

1994

Language:

english

File:

PDF, 2.19 MB

english, 1994

35

Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides

Inoue, Hideo, Hayase, Yoji, Imura, Akihiro, Iwai, Shigenori, Miura, Kazunobu, Ohtsuka, Eiko

Journal:

Nucleic Acids Research

Year:

1987

Language:

english

File:

PDF, 874 KB

english, 1987

36

Fukutin expression in mouse non-muscle somatic organs: its relationship to the hypoglycosylation of α-dystroglycan in Fukuyama-type congenital muscular dystrophy

Yoshiaki Saito, Tomoko Yamamoto, Eiko Ohtsuka-Tsurumi, Akira Oka, Masashi Mizuguchi, Masayuki Itoh, Thomas Voit, Yoichiro Kato, Makio Kobayashi, Kayoko Saito, Makiko Osawa

Journal:

Brain and Development

Year:

2004

Language:

english

File:

PDF, 956 KB

english, 2004

37

Pathological study of bronchospasms/tracheomalasia in patients with severe motor and intellectual disabilities

Eiko Ohtsuka, Masaharu Hayashi, Kimiko Hamano, Satoko Kumada, Akira Uchiyama, Kiyoko Kurata, Makiko Osawa

Journal:

Brain and Development

Year:

2005

Language:

english

File:

PDF, 154 KB

english, 2005

38

Autonomic dysfunction in cases of spinal muscular atrophy type 1 with long survival

Yasuo Hachiya, Hidee Arai, Masaharu Hayashi, Satoko Kumada, Wakana Furushima, Eiko Ohtsuka, Yasushi Ito, Akira Uchiyama, Kiyoko Kurata

Journal:

Brain and Development

Year:

2005

Language:

english

File:

PDF, 97 KB

english, 2005

39

Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis

Nobuyuki Kai, Katsuro Iwase, Kazuhide Imai, Eiko Nakahira, Miho Soma, Satoko Ohtsuka, Takeshi Yagi, Kazuto Kobayashi, Hisashi Koga, Masaki Takiguchi, Shigeki Yuasa

Journal:

Year:

2006

Language:

english

File:

PDF, 504 KB

english, 2006

40

Co-localization of fukutin and α-dystroglycan in the mouse central nervous system

Eiko Ohtsuka-Tsurumi, Yoshiaki Saito, Tomoko Yamamoto, Thomas Voit, Makio Kobayashi, Makiko Osawa

Journal:

Developmental Brain Research

Year:

2004

Language:

english

File:

PDF, 435 KB

english, 2004

41

A new Drosophila ultraviolet light-damaged DNA recognition endonuclease that selectively nicks a (6-4) photoproduct site

Mihoko Kai, Takeshi Todo, Masahito Wada, Haruko Ryo, Chikahide Masutani, Hiroyuki Kobayashi, Hiroshi Morioka, Eiko Ohtsuka, Fumio Hanaoka, Kengo Sakaguchi

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1998

Language:

english

File:

PDF, 257 KB

english, 1998

42

Reconstitution of Chemically Synthesized Ribooligonucleotides with Naturally Occurring tRNA Fragments

Eiko OHTSUKA, Satoshi NISHIKAWA, Mono IKEHARA, Shosuke TAKEMURA

Journal:

Year:

1976

Language:

english

File:

PDF, 348 KB

english, 1976

43

Joining of Synthetic Ribotrinucleotides with Defined Sequences Catalyzed by T4 RNA Ligase

Eiko OHTSUKA, Satoshi NISHIKAWA, Ryoichi FUKUMOTO, Shoji TANAKA, Alexander Fred MARKHAM, Morio IKEHARA, Masahiro SUGIURA

Journal:

Year:

1977

Language:

english

File:

PDF, 551 KB

english, 1977

44

Synthesis of 5′ Fragments of Formylmethionine Transfer Ribonucleic Acid and Their Reconstitution with a Natural Three-Quarter Molecule

Eiko OHTSUKA, Satoshi NISHIKAWA, Ryoichi FUKUMOTO, Haruki UEMURA, Toshiki TANAKA, Eiko NAKAGAWA, Tetsuo MIYAKE, Morio IKEHARA

Journal:

Year:

1980

Language:

english

File:

PDF, 524 KB

english, 1980

45

Recognition by restriction endonuclease EcoRI of deoxyoctanucleotides containing modified sugar moieties

Eiko OHTSUKA, Yoshizumi ISHINO, Kazuhiko IBARAKI, Morio IKEHARA

Journal:

Year:

1984

Language:

english

File:

PDF, 319 KB

english, 1984

46

Synthesis and expression of a human growth hormone (somatotropin) gene mutated to change cysteine-165 to alanine

Tomoko TOKUNAGA, Toshiki TANAKA, Morio IKEHARA, Eiko OHTSUKA

Journal:

Year:

1985

Language:

english

File:

PDF, 890 KB

english, 1985

47

The in vivo stability, maturation and aminoacylation of anticodon-substituted Escherichia coli initiator methionine tRNAs

Henri GROSJEAN, Suzy DE HENAU, Takefumi DOI, Akio YAMANE, Eiko OHTSUKA, Morio IKEHARA, Nicole BEAUCHEMIN, Krikor NICOGHOSIAN, Robert CEDERGREN

Journal:

Year:

1987

Language:

english

File:

PDF, 1.38 MB

english, 1987

48

Increase in nucleolytic activity of ribonuclease T1 by substitution of tryptophan 45 for tyrosine 45

Satoshi NISHIKAWA, Hiroshi MORIOKA, Tsuyoshi KIMURA, Yukari UEDA, Toshiki TANAKA, Seiichi UESUGI, Toshio HAKOSHIMA, Ken-ichi TOMITA, Eiko OHTSUKA, Morio IKEHARA

Journal:

Year:

1988

Language:

english

File:

PDF, 748 KB

english, 1988

49

Synthesis of a gene for the protein kinase domain of the epidermal growth factor receptor and its expression in Escherichia coli

Stuart N. FARROW, Hiroyuki KAMIYA, Kazunobu MIURA, Eiko OHTSUKA, Susumu NISHIMURA

Journal:

Year:

1989

Language:

english

File:

PDF, 466 KB

english, 1989

50

Effect of mutagenesis at each of five histidine residues on enzymatic activity and stability of ribonuclease H from Escherichia coli

Shigenori KANAYA, Katsuo KATAYANAGI, Kosuke MORIKAWA, Hideo INOUE, Eiko OHTSUKA, Morio IKEHARA

Journal:

Year:

1991

Language:

english

File:

PDF, 426 KB

english, 1991